Integrated nano system for liver-targeting co-delivery of genes/drugs and preparation method

US10512605B2 · kind B2 · utility

Assignees

• Jiangnan University · CN
• Max Planck Institute of Colloids and Interfaces · DE

Inventors

• Jian Yin · Hong Kong, CN
• Jing-Shan Hu · Hefei, CN
• Peter H. Seeberger · Potsdam, DE
• Zhou Ye · Fremont, US

Key dates

• Filing date: Dec 10, 2018
• Grant date: Dec 24, 2019
• Expiry date: Dec 10, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2320/32
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure discloses an integrated nano system for liver-targeting co-delivery of genes/drugs and a preparation method, belonging to the field of biomedicines. In the disclosure, a plurality of functions are integrated in a carrier having good biocompatibility and safety, a nucleic acid/drug-loading copolymer portion having a pH-stimulating response function is formed by poly(N,N-dimethylaminoethyl methacrylate) (PDMAEMA) grafted with poly(3-azido-2-hydroxypropylmethacrylate) (PGMA-N3), and a fluorescence-based imaging component Rhodamine B (RhB) and galactose are used as targeting ligands. The drug delivery system provided by the present disclosure is safe, is capable of taking a synergistic effect of gene/drug therapy, and is expected to play a great role in clinical application.