Blockade of inflammatory proteases with cyclic peptides

US10512669B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Michael E. Selsted · Los Angeles, US
• Dat Q. Tran · Anaheim, US

Key dates

• Filing date: Jun 1, 2012
• Grant date: Dec 24, 2019
• Expiry date: Jun 1, 2032

Classification

• Technology area (CPC F): Mechanical Engineering; Lighting; Heating
• CPC primary: F24F2203/1076
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Drug compositions for treatment of one or more inflammatory conditions can includes at least one of a θ-defensin, analog or derivative thereof. Inventive methods include researching θ-defensins, analogs or derivatives thereof for their efficacy with respect to anti-inflammatory effects, and providing such compositions to the marketplace for the purpose of treating inflammatory conditions. Of particular interest are drug compositions effective to produce clinically relevant inhibition of tumor necrosis factor alpha (TNF-α)-converting enzyme (TACE) or other proinflammatory proteases, and/or sheddases. it is contemplated that preferred compositions can be used to treat rheumatoid arthritis, inflammatory bowel disease, and other chronic inflammatory diseases, autoimmune diseases, cancer, and Alzheimer's, osteoarthritis, inflammation-related neurodegenerative and other inflammation-related diseases.