Adeno-associated virus factor VIII vectors, associated viral particles and therapeutic formulations comprising the same
US10512675B2 · kind B2 · utility
6Cited by
7References
25Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 23, 2016 |
| Grant date | Dec 24, 2019 |
| Priority date | — |
| Expiry date | Apr 10, 2037 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/015
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides adeno-associated virus (AAV) Factor VIII (FVIII)-encoding/expressing vectors and virus, including AAV FVIII vectors with high expression activity and AAV FVIII vectors that express full-length or truncated functional FVIII protein. The invention also relates to methods of making the herein described AAV FVIII vectors, recombinant AAV FVIII virus particles comprising or expressing such vectors, associated pharmaceutical formulations comprising the same and therapeutic uses thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.