Process for preparing darunavir amorphous
US10513527B2 · kind B2 · utility
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9Claims
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Key dates
| Filing date | Jan 8, 2016 |
| Grant date | Dec 24, 2019 |
| Priority date | — |
| Expiry date | Jan 8, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D493/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to medical chemistry technique field, particularly relates to a preparation method for amorphous darunavir crystal,The present invention provides a preparation method for preparing amorphous form of darunavir using an anti-solvent method. It can be a different method compared to the evaporation and concentration process disclosed in WO2011048604. Although the same with WO2013114382, anti-solvent are used, the target crystal form are truly different. The crystal form of WO2013114382 is solvent-free darunavir crystal, while an amorphous form of darunavir in the present application.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.