Mutant of L1 protein of human papillomavirus type 11

US10513541B2 · kind B2 · utility

Assignees

• XIAMEN UNIVERSITY · CN
• Xiamen Innovax Biotech Co., Ltd. · CN

Inventors

• Shaowei Li · Potomac, US
• Daning Wang · Fujian, CN
• Xinlin Liu · Fujian, CN
• Zhihai Li · Xiamen, CN
• Jun Zhang · Xiamen, CN
• Ningshao Xia · Fujian, CN

Key dates

• Filing date: Dec 2, 2016
• Grant date: Dec 24, 2019
• Expiry date: Dec 2, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2710/20071
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are a mutated HPV11 L1 protein (or a variant thereof), a sequence encoding the same, a method for preparing the same, and a virus-like particle comprising the same, wherein the protein (or a variant thereof) and the virus-like particle can induce the generation of neutralizing antibodies against at least two HPV types (e.g. HPV11 and HPV6), and therefore can be used to prevent infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum. Also disclosed is use of the protein and the virus-like particle in the manufacture of a pharmaceutical composition or a vaccine for preventing infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum.