Patent · US Active

Synthetic hammerhead ribozymes with ligand-responsive tertiary interactions

US10513702B2 · kind B2 · utility

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20Claims

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Assignee

The Board of Trustees of the Leland Stanford Junior University · US

Inventors

Andrew KENNEDY · Santa Clara, US
Christina D. Smolke · Menlo Park, US

Key dates

Filing date	Jun 17, 2016
Grant date	Dec 24, 2019
Priority date	—
Expiry date	Jun 26, 2036

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2330/31
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

A ligand-responsive hammerhead ribozyme is provided. In some embodiments, the ribozyme comprises: i. a first loop that has been replaced by an RNA aptamer that binds to a ligand; and ii. a second loop comprising a modified sequence, wherein the aptamer and the second loop interact in a ligand-dependent manner and autocatalytic cleavage of the ribozyme is ligand-responsive.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.