Patent · US Active

Exosomal loading using hydrophobically modified oligonucleotides

US10513710B2 · kind B2 · utility

3Cited by

1References

42Claims

0Family size

Assignee

University of Massachusetts · US

Inventors

Anastasia Khvorova · Boulder, US
Neil Aronin · Newton, US
Marie Cecile Didiot · Worcester, US
Reka Haraszti · Tübingen, DE

Key dates

Filing date	Apr 17, 2015
Grant date	Dec 24, 2019
Priority date	—
Expiry date	Apr 17, 2035

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2310/531
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

In one aspect, the invention relates to a method of loading exosomes with oligonucleotide cargo, by incubating an oligonucleotide comprising one or more hydrophobic modifications with a population of exosomes for a period of time sufficient to allow loading of the exosomes with the oligonucleotide. Exosomes loaded with hydrophobic ally modified oligonucleotide cargo, and uses thereof, are also provided.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.