Sequencing methods and kits
US10513732B2 · kind B2 · utility
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1References
9Claims
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Key dates
| Filing date | Jul 11, 2016 |
| Grant date | Dec 24, 2019 |
| Priority date | — |
| Expiry date | Mar 21, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/6869
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A method for detecting rare genomic variants in a population of cells is disclosed. The method can detect de novo mutations in bacteria and analyze the impact of various physiological conditions on mutation rate, even though such effects would be too subtle to detect using other methods. The method can be used for detection of low-frequency subpopulations in the microbiome or in cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.