Residence structures and related methods

US10517820B2 · kind B2 · utility

Assignees

• Massachusetts Institute of Technology · US
• The Brigham and Women's Hospital, Inc. · US
• TOKITAE LLC · US

Inventors

• Andrew Bellinger · Wellesley, US
• Shiyi Zhang · Shanghai, CN
• Carlo Giovanni Traverso · Newton, US
• Robert S. Langer · Newton, US
• Stacy Mo · Darien, US
• Tyler Grant · Arlington, US
• Mousa Jafari · Waltham, US
• Dean Liang Glettig · Cambridge, US
• Angela DiCiccio · San Francisco, US
• Lowell L. Wood, Jr. · Bellevue, US
• Philip A. Eckhoff · Bellevue, US

Key dates

• Filing date: Apr 9, 2019
• Grant date: Dec 31, 2019
• Expiry date: Apr 9, 2039

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Described are methods of making a gastric residence structure including an active substance. The methods may include forming one or more arms comprising a loadable polymeric component, wherein the loadable polymeric component includes one or more polymeric materials and at least one active substance. The methods may also include connecting the one or more arms to an elastic polymeric component using a separate linker component. The gastric residence structures may be configured to be folded and physically constrained during administration and may be configured to assume an open retention shape upon removal of a constraint. The change between the folded shape and the open retention shape may be mediated by the elastic polymeric component that undergoes elastic deformation when the residence structure is in the folded shape and recoils when the gastric residence structure assumes the open retention shape.