Nanoscale carriers for the delivery or co-delivery of chemotherapeutics, nucleic acids and photosensitizers

US10517822B2 · kind B2 · utility

Assignees

• THE UNIVERSITY OF CHICAGO · US
• The University of North Carolina at Chapel Hill · US

Inventors

• Wenbin Lin · Chicago, US
• Chunbai He · Chicago, US
• Demin Liu · Round Lake, US

Key dates

• Filing date: Nov 6, 2014
• Grant date: Dec 31, 2019
• Expiry date: Nov 6, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2320/32
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Nanoscale coordination polymer nanoparticles for the co-delivery of multiple therapeutic agents are described. The multiple therapeutic agents can include a combination of different chemotherapeutic agents, a combination of one or more chemotherapeutic agents and one or more nucleic acids, such as small interfering RNA (siRNA) or microRNA, a combination of one or more chemotherapeutic agents and a photosensitizer (i.e., for use in photodynamic therapy), or a plurality of different siRNAs. Pharmaceutical formulations including the nanoparticles, methods of using the nanoparticles to treat cancer, and methods of making the nanoparticles are also described.