Vaccines with higher carbohydrate antigen density and novel saponin adjuvant
US10517936B2 · kind B2 · utility
0Cited by
6References
16Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 6, 2014 |
| Grant date | Dec 31, 2019 |
| Priority date | — |
| Expiry date | Jan 6, 2034 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/6081
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides vaccines comprising carbohydrate antigen conjugated to a diphtheria toxin (DT) as a carrier protein, wherein the ratio of the number of carbohydrate antigen molecule to the carrier protein molecule is higher than 5:1. Also disclosed herein is a novel saponin adjuvant and methods to inhibit cancer cells, by administering an effective amount of the vaccine disclose herein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.