Vinyl compounds as FGFR and VEGFR inhibitors

US10519133B2 · kind B2 · utility

Assignees

• Medshine Discovery Inc. · CN
• HARBIN ZHENBAO PHARMACEUTICAL CO., LTD. · CN

Inventors

• Shuhui CHEN · Shanghai, CN
• Zhengxia Chen · Shanghai, CN
• Meibi Dai · Shanghai, CN
• Cheng Xie · Shanghai, CN
• Peng Li · New York, US
• Yang Zhang · San Diego, US
• Guibai Liang · Nanjing, CN
• Qiang Wang · Philadelphia, US
• Jiangpeng Liao · Shanghai, CN
• Fei Sun · Shanghai, CN
• Guoping HU · Shanghai, CN
• Jian Li · Shanghai, CN

Key dates

• Filing date: Aug 3, 2016
• Grant date: Dec 31, 2019
• Expiry date: Aug 3, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

FGFR and VEGFR inhibitors are provided, and compounds represented by formula (1) or formula (II) as FGFR and VEGFR inhibitors, pharmaceutically acceptable salts or tautomers thereof are specifically disclosed.