KRAS G12C inhibitors and methods of using the same

US10519146B2 · kind B2 · utility

Assignee

• AMGEN INC. · US

Inventors

• Brian Alan LANMAN · Calabasas, US
• Jian Chen · Camarillo, US
• Anthony B. Reed · Newbury Park, US
• Victor J. Cee · Thousand Oaks, US
• Longbin Liu · Thousand Oaks, US
• David John Kopecky · West Hollywood, US
• Patricia Lopez · Calabasas, US
• Ryan Wurz · Newbury Park, US
• Thomas Nguyen · Newbury Park, US
• Shon Booker · Thousand Oaks, US
• Nobuko Nishimura · Calabasas, US
• Youngsook Shin · Emeryville, US
• Nuria A. Tamayo · Newbury Park, US
• John Gordon Allen · Newbury Park, US
• Jennifer R. Allen · Newbury Park, US

Key dates

• Filing date: May 21, 2018
• Grant date: Dec 31, 2019
• Expiry date: May 21, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.