Patent · US Active

Amine solvate of sodium-glucose linked transporter inhibitor, and preparation method and application thereof

US10519183B2 · kind B2 · utility

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19Claims

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Assignee

Youngene Therapeutics Co., Ltd. · CN

Inventors

Lei Zhang · Beijing, CN
Yuan Wang · Beijing, CN

Key dates

Filing date	Mar 27, 2017
Grant date	Dec 31, 2019
Priority date	—
Expiry date	Mar 27, 2037

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07B2200/13
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Disclosed are an amine solvate of a sodium-glucose linked transporter (SGLT) inhibitor, and a preparation method and application thereof. The SGLT inhibitor is (1S,2S,3S,4R,5S)-5-(3-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methyl)-4-ethylbenzyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol. Further provided is a crystalline compound of the amine solvate, a pharmaceutical composition comprising the amine solvate, and an application of the amine solvate in preparing an SGLT-inhibiting pharmaceutical product.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.