Modified lipopolysaccharide glycoform and method of use

US10525126B2 · kind B2 · utility

Assignees

• THE TRUSTEES OF PRINCETON UNIVERSITY · US
• President and Fellows of Harvard College · US

Inventors

• Thomas J. Silhavy · Montgomery, US
• Marcin Grabowicz · Princeton, US
• Daniel Kahne · Brookline, US
• Matthew Lebar · Boston, US
• Dorothee Andres · Potsdam, DE

Key dates

• Filing date: May 4, 2017
• Grant date: Jan 7, 2020
• Expiry date: Aug 10, 2037

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2039/55594
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure generally relates to genetic engineering of bacteria. More particularly, the present disclosure describes genetic engineering of E. coli to create mutant O-antigen ligase, as well as novel lipopolysaccharide molecules resulting from that genetic engineering. Methods for using those novel molecules are also described.