Polyglycerol derivative and a method for manufacturing the same

US10525141B2 · kind B2 · utility

Assignee

• FREIE UNIVERSITÄT BERLIN · DE

Inventors

• Rainer Haag · Berlin, DE
• Sabine Reimann · Berlin, DE
• Jens Dernedde · Berlin, DE

Key dates

• Filing date: Apr 15, 2016
• Grant date: Jan 7, 2020
• Expiry date: Apr 15, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08G83/004
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

It is provided a polyglycerol derivative, comprising a dendritic polyglycerol backbone and at least one substituent in the nature of a covalently bound negatively charged group chosen from the group consisting of sulfates, sulfonates, phosphates, phosphonates, bisphosphonates, carboxylates and combinations thereof. The substituent is bound to the polyglycerol backbone via a linker, the linker being chosen from the group consisting of moieties being or comprising a carbamate group, an ester group, an orthoester group, an amide group, a disulfide bridge group, an acetal group, an imine group and combinations thereof.