Formation of nanometric core-shell particles having a metal oxide shell
US10525433B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 12, 2007 |
| Grant date | Jan 7, 2020 |
| Priority date | — |
| Expiry date | Apr 16, 2033 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P1/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A process for preparing nanocapsules having a core-shell structure, comprising:(a) preparing an oil-in-water emulsion by emulsification of an oily phase that comprises a core material, in an aqueous phase, under high shear forces, wherein one or both of the oily phase, and the aqueous phase comprises a sol-gel precursor; (b) subjecting the emulsion obtained in (a) to a high pressure homogenization to obtain a nano-emulsion; and (c) applying conditions for hydrolyzing and polycondensing the sol-gel precursor to obtain nanocapsules having a metal oxide shell encapsulating the core material, said nanocapsules have a particle size distribution of: d10=10-80 nm, d50=30-200 nm, and d90=70-500 nm, in diameter. The invention also relate to nanocapsules having the above particle size distribution and to composition comprising the nanocapsules.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.