Patent · US Active

Oxidative modification improves the drugability of cell penetrating peptides as drug carriers

US10526369B2 · kind B2 · utility

0Cited by

2References

9Claims

0Family size

Inventors

Yu-Min Lin · Hsinchu, TW
Wei-Chen Chen · Redmond, US
Win-Chin Chiang · Newburgh, US
Ting Lian Chang
Chun-Hung Kuo · Taoyuan, TW

Key dates

Filing date	Apr 6, 2017
Grant date	Jan 7, 2020
Priority date	—
Expiry date	Apr 6, 2037

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/10
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention provides a cell penetrating peptide dimer by oxidative modification, in which each monomer is connected with each other by the disulfide linkage. The drugability of the peptide dimer has been improved through enhancing stability, reducing proteolysis, retaining permeability and increasing heparan sulfate binding specificity. The modified peptide products can be used to deliver drug molecules as a suitable drug carrier for targeted therapy.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.