Methods for identifying T-cell receptor antigens
US10526598B2 · kind B2 · utility
8Cited by
60References
17Claims
0Family size
Assignee
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Key dates
| Filing date | Apr 23, 2019 |
| Grant date | Jan 7, 2020 |
| Priority date | — |
| Expiry date | Apr 23, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/20
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present disclosure automated methods for creating cell surface display libraries, where the cells of the library display engineered peptides on their cell surfaces for identification of antigens that bind to T-cell receptors. The engineered peptides are preferably expressed in the cells under conditions that provide both secretion and display of the engineered peptides on the cell surfaces, thus providing access of the engineered peptide antigens to identify potential TCR binding targets. The cell libraries cab be engineered using an automated editing system that provides for one or more targeted edits per cell.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.