RNA polymerase variants

US10526629B2 · kind B2 · utility

Assignee

• ModernaTX, Inc. · US

Inventors

• Amy E. Rabideau · Waltham, US
• Athanasios Dousis · Pasadena, US
• Kanchana Ravichandran · Cambridge, US
• Elissa Hobert · Cambridge, US

Key dates

• Filing date: Jun 5, 2019
• Grant date: Jan 7, 2020
• Expiry date: Jun 5, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Y207/11023
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present disclosure provides, in some aspects, variant RNA polymerases, the use of which increases transcription efficiency while reducing the number of double-stranded RNA contaminates and run-on transcripts produced during an in vitro transcription reaction.