Isobaric mass labels

US10527629B2 · kind B2 · utility

Assignee

• ELECTROPHORETICS LIMITED · GB

Inventors

• Andrew Hugin Thompson · Cambridge, GB
• Stefan Kienle · Frankfurt, DE
• Karsten Kuhn · Dortmund, DE
• Nikolai Woellmer · Frankfurt, DE

Key dates

• Filing date: Jun 12, 2015
• Grant date: Jan 7, 2020
• Expiry date: Oct 10, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/05
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present invention relates to a set of two or more mass labels. Each mass label comprises: X-L-M-Re; X is a reporter moiety having exact mass; L is a bond cleavable by collision in a mass spectrometer; M is a mass modifier; Re is a) a reactive functionality for attaching the mass label to an analyte or b) the analyte. Each mass label in the set has the same integer mass; wherein the set comprises two or more subsets of mass labels, each subset comprising one or more mass labels; wherein, when the subset comprises two or more mass labels, the exact mass of the reporter moiety X of each mass label in the subset is different from the exact mass of the reporter moiety X of the mass labels in the same subset and in all other subsets; each mass label is distinguishable by mass spectrometry.