Bisphosphonic acid derivative and application for same
US10532065B2 · kind B2 · utility
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17Claims
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Key dates
| Filing date | Dec 18, 2015 |
| Grant date | Jan 14, 2020 |
| Priority date | — |
| Expiry date | Dec 18, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/6561
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The novel bisphosphonic acid ester derivatives represented by the following formula (1): Y—Cy—(NH)m—(CH2)n—C(X)(PO(OR1)(OR2))2 (1) wherein each symbol is as defined in the DESCRIPTION, which has an amino group substituted by a heterocyclic group or a heterocyclic group containing a nitrogen atom, and the acid moiety is esterified with a POM group, an n-butanoyloxymethyl (BuOM) group and the like, exhibit a superior direct or indirect cytotoxicity effect on tumor cells and virus infected cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.