Methods and compositions for modulating the immune system with arginase I
US10532086B2 · kind B2 · utility
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18Claims
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Key dates
| Filing date | Dec 6, 2017 |
| Grant date | Jan 14, 2020 |
| Priority date | — |
| Expiry date | Feb 12, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y305/03001
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods and compositions comprising recombinant Arginase I proteins which are capable of depleting the plasma arginine levels in a subject are disclosed. The methods and compositions can be used to modulate the activity of the immune system in a subject. Modulation of the immune system is useful in the treatment of immune disorders and in preventing rejection of a transplanted organ, tissue, or cell. The methods and compositions can also be used to treat a bone condition of a subject.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.