Mineralized foot-and-mouth disease virus like particles, and preparation method and use thereof

US10532092B2 · kind B2 · utility

Assignees

• LANZHOU VETERINARY RESEARCH INSTITUTE, CHINESE ACADEMY OF AGRICULTURAL SCIENCES · CN
• ZHEJIANG UNIVERSITY · CN

Inventors

• Huichen GUO · Lanzhou, CN
• Shiqi SUN · Lanzhou, CN
• Ping Du · Rahway, US
• Zhidong TENG · Lanzhou, CN
• Ruikang Tang · Lanzhou, CN
• Ruibo ZHAO · Lanzhou, CN
• Jiaxi Ru · Lanzhou, CN
• Yanquan WEI · Lanzhou, CN
• Yun ZHANG · Lanzhou, CN
• Yuan Gao · San Diego, US
• Junwu Ma · Lanzhou, CN
• Xiangtao Liu · Lanzhou, CN
• Hong Yin · Hangzhou City, CN

Key dates

• Filing date: Jul 4, 2018
• Grant date: Jan 14, 2020
• Expiry date: Jul 4, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2770/32134
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Foot-and-mouth disease virus like particles, the particles including a structural protein VP0, a structural protein VP1 including a mineralization peptide, a structural protein VP3, and a calcium phosphate coat. The structural protein VP1 including a mineralization peptide is encoded by a gene sequence represented by SEQ ID NO. 7, SEQ ID NO. 8 or SEQ ID NO. 9. The structural protein VP0 is encoded by a gene sequence represented by SEQ ID NO. 2. The structural protein VP3 is encoded by a gene sequence represented by SEQ ID NO. 3. The calcium phosphate coat covers the structural protein VP0, the structural protein VP1 including a mineralization peptide, and the structural protein VP3.