Precursor miRNA and applications in tumor therapy thereof
US10533173B2 · kind B2 · utility
2Cited by
2References
20Claims
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Key dates
| Filing date | May 5, 2016 |
| Grant date | Jan 14, 2020 |
| Priority date | — |
| Expiry date | May 5, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2330/51
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided are a new precursor miRNA and the applications in tumor therapy thereof. The precursor miRNA, from 5′- to 3′-end thereof, has the structure represented by formula (I). B1 is an anti-miRNA and/or siRNA to be expressed; B2 is a sequence substantially or completely complementary to B1, and B2 is not complementary to C; C is a sequence with stem-loop structure; A1 and A2 are independently hydrogen or optionally a RNA sequence consisting of 4 to 5 bases. The precursor miRNA can be processed to form an anti-miRNA and/or siRNA in hosts.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.