Delayed release pharmaceutical composition of pantoprazole and process for formulation thereof
US10537562B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 6, 2017 |
| Grant date | Jan 21, 2020 |
| Priority date | — |
| Expiry date | Oct 6, 2037 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/5026
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention discloses stable delayed release multiparticulate powder for oral suspension of proton pump inhibitor compounds comprising: a) a core with an effective amount of proton pump inhibitor and at least one or more pharmaceutical excipients, b) at least one water-soluble seal coating over core c) at least one enteric coating layer over the seal coat wherein the said core comprises disintegrant (0-10%) and/or surfactant (0-2%) w/w of core. The prior art discloses restrictive formulation technique and suggest high amount of various excipients to achieve desired technical attributes. The prepared test formulations exhibited desired pharmaceutical technical attributes like drug release, assay, stability, no polymorphic change, reduced sticking to nasogastric and gastronomy tubes, and packaging material.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.