Method of isolating anti-viral ingredients from Baphicacanthus cusia, compositions comprising them and their medical use

US10537601B2 · kind B2 · utility

Assignee

• Macau University of Science and Technology · CN

Inventors

• Jing Wang · Beijing, CN
• Zhi-Hong Jiang · Taipa, CN
• Qi-Tong Feng · Taipa, CN
• Guo-Yuan Zhu · Macau, CN
• Wei Gao · Fort Washington, US
• Zifeng Yang
• Nanshan Zhong

Key dates

• Filing date: Apr 4, 2016
• Grant date: Jan 21, 2020
• Expiry date: Sep 28, 2037

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2236/55
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a method of isolating at least one ingredient with anti-viral efficacy from Baphicacanthus cusia. The ingredient can be an alkaloid, a triterpenoid, a lignan, a phenylethanoid, a sesquiterpene lactone, or a flavonoid. Two new alkaloids are produced, which have not been previously reported. Moreover, the method isolates 12 compounds which could not or have not been previously isolated. A pharmaceutical composition includes the at least one ingredient and at least one pharmaceutical tolerable excipient. A method of treating a subject suffering from a viral disease includes administering at least one ingredient isolated from Baphicacanthus cusia.