Sulfonylureas and related compounds and use of same

US10538487B2 · kind B2 · utility

Assignees

• The University Of Queensland · AU
• THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN · IE

Inventors

• Luke O'Neill · Dublin, IE
• Rebecca Coll · Brisbane, AU
• Matthew Cooper · Cambridge, GB
• Avril Robertson · Norwood, AU
• Kate Schroder · Parramatta, AU

Key dates

• Filing date: Feb 16, 2016
• Grant date: Jan 21, 2020
• Expiry date: Feb 16, 2036

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides for certain sulfonyl ureas and related compounds which have advantageous properties and show useful activity in the inhibition of activation of the NLRP3 inflammasome. Such compounds are useful in the treatment of a wide range of disorders in which the inflammation process, or more specifically the NLRP3 inflammasome, have been implicated as being a key factor.