4,5-substituted picolinamide and picolinonitrile metabotropic glutamate receptor 2 negative allosteric modulators

US10538491B2 · kind B2 · utility

Assignee

• VANDERBILT UNIVERSITY · US

Inventors

• P. Jeffrey Conn · Brentwood, US
• Craig W. Lindsley · Brentwood, US
• Kyle A. Emmitte · Durham, US
• Andrew S. Felts · Brentwood, US
• Katrina A. Bollinger · Murfreesboro, US

Key dates

• Filing date: Mar 16, 2016
• Grant date: Jan 21, 2020
• Expiry date: Mar 28, 2036

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/277
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

4,5-Substituted Picolinamide and picolinonitrile compounds of formula (I), where R4 is CONH2 or CN and R1 is an optionally substituted aryl or heteroaryl, are negative allosteric modulators of the metabotropic glutamate receptor 2 (mGlu2). The compounds and pharmaceutical compositions including the compounds may be useful for treating depression, anxiety, obsessive-compulsive disorder, cognitive disorders, Alzheimer's disease, or autism spectrum disorders in a subject.