Patent · US Active

Decarboxylative cross-coupling and applications thereof

US10538509B2 · kind B2 · utility

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28Claims
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Assignee

Inventors

Key dates

Filing dateMar 27, 2015
Grant dateJan 21, 2020
Priority date—
Expiry dateAug 16, 2035

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07C2602/10
  • WIPO fieldOrganic fine chemistry
  • WIPO sectorChemistry

Abstract

Methods described herein enable the production of numerous molecular species through decarboxylative cross-coupling via use of photoredox and transition metal catalysts. A method described herein, in some embodiments, comprises providing a reaction mixture including a photoredox catalyst, a transition metal catalyst, a coupling partner and a substrate having a carboxyl group. The reaction mixture is irradiated with a radiation source resulting in cross-coupling of the substrate and coupling partner via a mechanism including decarboxylation, wherein the coupling partner is selected from the group consisting of a substituted aromatic compound and a substituted aliphatic compound.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.