Heteroaryls and uses thereof

US10538533B2 · kind B2 · utility

Assignee

• Millennium Pharmaceuticals, Inc. · US

Inventors

• Indu T. Bharathan · Somerville, US
• Chris Blackburn · Natick, US
• Jeffrey P. Ciavarri · Reading, US
• Jouhara Chouitar · Stoughton, US
• Courtney A. Cullis · Bedford, US
• Natalie D'Amore · Lynnfield, US
• Paul E. Fleming · Wellesley, US
• Kenneth M. Gigstad · Westford, US
• Krista E. Gipson · Medford, US
• Mario Girard · Quincy, US
• Yongbo Hu · Winchester, US
• Janice Lee · Cambridge, US
• Gang Li · Beijing, CN
• Mansoureh Rezaei · Quincy, US
• Michael D. Sintchak · Winchester, US
• Francois Soucy · Stoneham, US
• Stephen G. Stroud · Medford, US
• Tricia J. Vos · Medford, US
• Tzu-Tshin Wong · Belmont, US
• He Xu · Needham, US
• Tianlin Xu · Shrewsbury, US
• Yingchun Ye · Belmont, US

Key dates

• Filing date: Aug 1, 2017
• Grant date: Jan 21, 2020
• Expiry date: Aug 1, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a compound of formula I: and pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3, R4, R5, L1, L2, m, and n, are as described in the specification. Such compounds are inhibitors of VPS34 and thus useful for treating proliferative, inflammatory, or cardiovascular disorders.