Methods and compositions for blocking off-target nucleic acids from cleavage by CRISPR proteins
US10538750B2 · kind B2 · utility
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20Claims
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Key dates
| Filing date | Feb 24, 2017 |
| Grant date | Jan 21, 2020 |
| Priority date | — |
| Expiry date | Jul 16, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/53
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
This invention relates to reagents and methods for increasing specificity and efficiency of genome editing by CRISPR associated (Cas) protein systems, more particularly by Cas:guide RNA complexes, by blocking off-target nucleic acids from cleavage by Cas:guide RNA complexes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.