Method for preparation of thrombin
US10538754B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Feb 6, 2015 |
| Grant date | Jan 21, 2020 |
| Priority date | — |
| Expiry date | Mar 8, 2035 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/745
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention is directed to methods for the production of thrombin from a source of prothrombin using a given BaSO4 reagent as an adsorbent of prothrombin as well as methods for evaluating the suitability of a given BaSO4 reagent for use in preparation of thrombin. In at least one embodiment, the method includes contacting a sample of the given BaSO4 reagent with a source of prothrombin to obtain BaSO4-adsorbed prothrombin, and subsequently evaluating the pro-coagulant activity of the BaSO4-adsorbed prothrombin. In another embodiment, the method includes the step of evaluating relative to the pro-coagulant activity of normal mammalian plasma.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.