System for interpretation of image patterns in terms of anatomical or curated patterns

US10540536B2 · kind B2 · utility

Assignees

• Katholieke Universiteit Leuven, KU LEUVEN R&D · BE
• VANDERBILT UNIVERSITY · US

Inventors

• Richard Caprioli · Brentwood, US
• Bart De Moor · Bierbeek, BE
• Raf Van De Plas · Delft, NL
• Nico Verbeeck · Tremelo, BE
• Etienne Waelkens · Rotselaar, BE

Key dates

• Filing date: Aug 3, 2015
• Grant date: Jan 21, 2020
• Expiry date: Jan 3, 2036

Classification

• Technology area (CPC G): Physics
• CPC primary: G06T2207/30048
• WIPO field: Computer technology
• WIPO sector: Electrical engineering

Abstract

Imaging mass spectrometry (IMS) has become a prime tool for studying the distribution of biomolecules in tissue. Although IMS data sets can become very large, computational methods have made it practically feasible to search these experiments for relevant findings. However, these methods lack access to an important source of information that many human interpretations rely upon: anatomical insight. In this work, this need is addressed by (1) integrating a curated anatomical data source with an empirically acquired IMS data source, establishing an algorithm-accessible link between them; and (2) demonstrating the potential of such an IMS-anatomical atlas link by applying it toward automated anatomical interpretation of ion distributions in tissue.