Patent · US Active

Polyplex of double-stranded RNA and polymeric conjugate

US10543232B2 · kind B2 · utility

4Cited by

5References

23Claims

0Family size

Assignee

TARGIMMUNE THERAPEUTICS AG · CH

Inventors

Alex Levitzki · Jerusalem, IL
Salim Joubran · Lod, IL
Alexei Shir · Jerusalem, IL
Maya Zigler · Basel, CH
Alaa Talhami · Arraba, IL
Yael Langut · Haifa, IL

Key dates

Filing date	Mar 8, 2019
Grant date	Jan 28, 2020
Priority date	—
Expiry date	Mar 8, 2039

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2310/53
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A polyplex of a double stranded RNA (dsRNA) and a polymeric conjugate consists of a linear polyethyleneimine (PEI) covalently linked to one or more polyethylene glycol (PEG) moieties. Each PEG moiety is conjugated via a linker to a targeting moiety capable of binding to a cancer antigen. Exemplary cancer antigens include epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2) and prostate surface membrane antigen (PSMA).

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.