Peptides comprising non-natural amino acids and methods of making and using the same
US10543255B2 · kind B2 · utility
1Cited by
55References
20Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 19, 2017 |
| Grant date | Jan 28, 2020 |
| Priority date | — |
| Expiry date | Sep 19, 2037 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to novel compositions comprising analogs of naturally occurring polypeptides, wherein the analog comprises an α-amino acid and at least one β-amino acid. Administration of the compositions may be used for effecting treatment or prevention of a plurality of disease states caused by dysfunctional biochemical or biological pathways. The compositions and methods of this invention are particularly useful to identify novel therapeutic modulators of in-vivo receptor activity with extended half-lives and relevant bioactivity as compared to the naturally translated polypeptides upon which the analogs are derived.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.