Neisseria meningitidis compositions and methods thereof

US10543267B2 · kind B2 · utility

Assignee

• PFIZER INC. · US

Inventors

• Kathrin Ute Jansen · Doylestown, US
• Annaliesa Sybil Anderson · Upper Saddle River, US
• Judith Absalon · New York, US
• Jose Miguel Aste-Amezaga · Harleysville, US
• Johannes Frederik Beeslaar · Farnham, GB
• David Cooper · Rochester, US
• John Erwin Farley · Rochester, US
• Leah Diane Fletcher · Richmond, US
• Shannon Lea Harris · Nanuet, US
• Thomas Richard Jones · New City, US
• Isis Kanevsky · New York, US
• Lakshmi Khandke · Nanuet, US
• Paul Liberator · Holmdel, US
• John Lance Perez · Doylestown, US
• Lynn Marie Phelan · Lake Hiawatha, US
• Gary W. Zlotnick · New Windsor, US

Key dates

• Filing date: Nov 20, 2018
• Grant date: Jan 28, 2020
• Expiry date: Nov 20, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2770/32434
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

In one aspect, the invention relates to a composition including a factor H binding protein (fHBP) and a Neisseria meningitidis non-serogroup B capsular polysaccharide. The invention further relates to uses of a composition that includes fHBP, such as, for example, uses to elicit an immune response against N. meningitidis serogroup B strains and non-serogroup B strains. The compositions and methods described herein are directed to administration in humans, including adults, adolescents, toddlers, and infants.