Anthraquinone analogs and methods of making and using thereof

US10544090B2 · kind B2 · utility

Assignees

• Georgia State University Research Foundation · US
• EMORY UNIVERSITY · US
• Children's Healthcare of Atlanta · US

Inventors

• Binghe Wang · Marietta, US
• Chaofeng Dai · Wilmington, US
• Alexander Draganov · Atlanta, US
• Xiaochuan Yang · Towson, US
• Guojing Sun · Atlanta, US
• Chunhao Yang · Shanghai, CN
• Weixuan Chen · Cambridge, US
• Nanting Ni · Goleta, US
• Muxiang Zhou · Tucker, US
• Lubing Gu · Tucker, US

Key dates

• Filing date: Jul 10, 2013
• Grant date: Jan 28, 2020
• Expiry date: Apr 30, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2603/24
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Rhein analogues that exhibit anti-proliferative activity, particular against cancer cells, are described herein. In some embodiments, the compounds contain a flat or planar ring system. Such rings system by facilitate non-covalent binding of the compounds to the DNA complex, such as by intercalation. In some embodiment, the compounds contain a flat or planar ring system as described above and one or more substituents which are alkylating moieties, electrophilic groups or Michael acceptors or groups which contain one or more alkylating moieties, electrophilic groups and/or Michael acceptors. The compounds described herein can also contain one more functional groups to improve the solubility of the compounds.