Biaryl kinase inhibitors

US10544120B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Joanne J. Bronson · Madison, US
• Ling Chen · Shanghai, CN
• Jonathan L. Ditta · Meriden, US
• Carolyn Diane Dzierba · Middletown, US
• Prasada Rao Jalagam · Bengaluru, IN
• Guanglin Luo · Newtown, US
• John E. Macor · Guilford, US
• Tarun Kumar Maishal · Bengaluru, IN
• Susheel Jethanand Nara · Mumbai, IN
• Ramkumar Rajamani · Wallingford, US
• Ramesh Kumar Sistla · Bengaluru, IN
• Soodamani Thangavel · Krishnagiri, IN

Key dates

• Filing date: Sep 29, 2016
• Grant date: Jan 28, 2020
• Expiry date: Sep 29, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present disclosure is directed to biaryl compounds of formula (I) which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds and their use for treating e.g. pain, Alzheimer's disease, Parkinson's disease and schizophrenia.