Patent · US Active

4-substituted coumarin derivatives and preparation methods and uses thereof

US10544134B2 · kind B2 · utility

0Cited by

1References

21Claims

0Family size

Assignee

GUIZHOU BAILING GROUP PHARMACEUTICAL CO., LTD. · CN

Inventors

Lijuan Chen · Dongguan, CN
Yuquan Wei · Chengdu, CN

Key dates

Filing date	Feb 29, 2016
Grant date	Jan 28, 2020
Priority date	—
Expiry date	Feb 29, 2036

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D409/14
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention pertains to the field of chemical medicine, particularly to 4-substituted coumarin derivatives and preparation methods and applications thereof. The invention provides 4-substituted coumarin derivatives with a structural formula as shown in Formula I. The invention also provides preparation methods and applications for the above 4-substituted coumarin derivatives. The compounds provided in the invention have strong anti-tumor activity with IC50 for plural tumor cell lines between 0.01-5 nM, and it also performs better to inhibit microtubule polymerization and has diversified biological activities and low toxicity, providing new options for drug-sensitive and drug-resistant tumor cells.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.