Deuterated chenodeoxycholic acid derivative and pharmaceutical composition comprising compound thereof
US10544185B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 16, 2016 |
| Grant date | Jan 28, 2020 |
| Priority date | — |
| Expiry date | Feb 16, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B2200/05
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are deuterated chenodeoxycholic acid derivatives and pharmaceutical compositions containing the deuterated chenodeoxycholic acid derivatives. In particular, disclosed is a deuterated chenodeoxycholic acid derivative of formula (I), or a crystal form, pharmaceutically acceptable salt, hydrate or solvate thereof, and a pharmaceutical composition containing the same. The deuterated chenodeoxycholic acid derivatives of formula (I) can be used to treat and/or prevent diseases related to the farnesoid X receptor (FXR) and/or G-protein coupled bile acid receptor, such as nonalcoholic steatohepatitis, nonalcoholic fatty liver diseases, gallstones, primary biliary cirrhosis, and cirrhosis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.