Anti-Rho GTPase conformational single domain antibodies and uses thereof
US10544210B2 · kind B2 · utility
1Cited by
0References
10Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Feb 2, 2016 |
| Grant date | Jan 28, 2020 |
| Priority date | — |
| Expiry date | May 8, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2015/8518
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to active form specific anti-Rho GTPase conformational single domain antibodies and their uses in particular in the therapeutic and diagnostic fields. In particular, the present invention relates to a single domain antibody wherein the amino acid sequences of CDR1-IMGT, CDR2-IMGT and CDR3-IMGT have at least 90% of identity with the amino acid sequences of the CDR1-IMGT, CDR2-IMGT and CDR3-IMGT of the H12, B6, 4P75, 4SP1, 4SNP36, 4SNP61, 5SP10, 5SP11, 5SP58, 5SNP47, 5SNP48, 5SNP65, B20, B15, B5, B71, E3, A6, G12, NB61, 212B, 111B or 404F (hs2dAb) single domain antibody which are defined in Table B.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.