Method of increasing proliferation of bone marrow mononuclear cells expressing STRO1-dim
US10544394B2 · kind B2 · utility
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2Claims
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Key dates
| Filing date | Aug 27, 2014 |
| Grant date | Jan 28, 2020 |
| Priority date | — |
| Expiry date | Aug 27, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2502/13
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to methods of enhancing proliferation and/or survival of mesenchymal precursor cells (MPC) and/or progeny derived therefrom in vitro or in vivo comprising exposing the MPC or progeny to SDF-1 or analog thereof. The invention also relates to compositions comprising isolated MPCs or progeny derived therefrom and SDF-1 or analogues thereof. The present invention also relates to using such methods and compositions for ex vivo or in vivo bone formation in mammals.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.