Multiplexed diagnostic to recognize concentrations of related proteins and peptides
US10545158B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 28, 2015 |
| Grant date | Jan 28, 2020 |
| Priority date | — |
| Expiry date | Jan 2, 2037 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/635
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Disclosed are methods and systems for determining concentrations of a target molecule and a variant thereof in a sample. The sample can comprise or be suspected to comprise a target molecule and at least one variant thereof and is exposed to one or more recognition elements that bind to the target molecule and/or the at least one variant. A signal is detected that is associated with the binding of the target molecule and/or a signal is detected that is associated with the binding of the at least one variant to the one or more recognition elements. The concentration of the target molecule and/or the at least one variant thereof is determined based on the signals. The system can comprise a receiver adapted to receive a sample comprising or suspected to comprise a target molecule and the at least one variant thereof, the receiver comprising one or more recognition elements that bind to one or more epitopes in the target molecule and/or the at least one variant thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.