Pharmaceutical composition for oral administration

US10548845B2 · kind B2 · utility

Assignee

• ASTELLAS PHARMA INC. · JP

Inventors

• Yumiko Suda · Tokyo, JP
• Toshiro Sakai · Tokyo, JP
• Ryo Kojima · Tokyo, JP
• Dal Oyama · Tokyo, JP
• Koji Nishimura · Tokyo, JP
• Kumi Naiki · Tokyo, JP

Key dates

• Filing date: Apr 27, 2016
• Grant date: Feb 4, 2020
• Expiry date: Apr 27, 2036

Classification

• Technology area (CPC —): General

Abstract

Disclosed is a pharmaceutical composition for oral administration, comprising 1-{5-[(5-{[(2R)-2-ethylpyrrolidin-1-yl]methyl}-4-[4-methoxy-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl)carbamoyl]pyrazin-2-yl}pyperidine-4-carboxylic acid, which is a compound having pH-dependent solubility, or a pharmaceutically acceptable salt thereof, and a cellulose derivative. In the pharmaceutical composition for oral administration, the solubility and absorbability of the drug are improved.