Nanoparticulate phosphate adsorbent on the basis of maghemite or maghemite/magnetite, production and uses thereof

US10548874B2 · kind B2 · utility

Assignee

• CHARITÉ—UNIVERSITÄTSMEDIZIN BERLIN · DE

Inventors

• Susanne Wagner · Mittenwalde, DE
• Matthias Taupitz · Teltow, DE
• Eyk Schellenberger · Berlin, DE
• Jörg SCHNORR · Oranienburg, DE
• Monika Ebert · Teltow, DE
• Gesche Genter · Berlin, DE
• Harald Kratz · Berlin, DE

Key dates

• Filing date: Mar 7, 2014
• Grant date: Feb 4, 2020
• Expiry date: May 22, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C01P2004/64
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a phosphate adsorbent on the basis of maghemite or maghemite/magnetite comprising (i) an iron oxide core comprising a crystal structure of inverse spinel iron oxide, (ii) a coating selected from monomeric carbohydrates, in particular monosaccharides or disaccharides, alditols, or mixtures thereof, and/or (iii) a pharmaceutical excipient selected from polymeric carbohydrates, wherein the phosphate adsorbent has the form of nanoparticles with a particle size of the iron oxide core (i) of less than 20 nm. The present invention further relates to a method for the production of a phosphate adsorbent on the basis of maghemite or maghemite/magnetite, to pharmaceutical compositions comprising the phosphate adsorbent, and to medical uses thereof, especially for the prevention and/or treatment of hyperphosphatemia.