Patent · US Active

Compounds, compositions, and methods of increasing CFTR activity

US10548878B2 · kind B2 · utility

6Cited by

12References

23Claims

0Family size

Assignee

Proteostasis Therapeutics, Inc. · US

Inventors

Benito Munoz · San Diego, US
Cecilia M. Bastos · Grafton, US
John D. Miller · Arvada, US

Key dates

Filing date	Jul 25, 2016
Grant date	Feb 4, 2020
Priority date	—
Expiry date	Jul 25, 2036

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D417/12
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present disclosure features compounds such as those having the Formulae (I) and (II), which can increase cystic fibrosis transmembrane conductance regulator (CFTR) activity as measured in human bronchial epithelial (hBE) cells. The present disclosure also features methods of treating a condition associated with decreased CFTR activity or a condition associated with a dysfunction of proteostasis comprising administering to a subject an effective amount of a disclosed compound, such as a compound of Formula (I) or (II).

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.