Therapeutic compositions for neutralizing type I interferons, and methods of use

US10548946B2 · kind B2 · utility

Assignee

• The Government of the United States, as represented by the Secretary of the Army · US

Inventors

• Joseph Golden · Hagerstown, US
• Jay Hooper · New Market, US

Key dates

• Filing date: Dec 1, 2017
• Grant date: Feb 4, 2020
• Expiry date: Dec 1, 2037

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P37/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The inventions describe here cover therapeutic compositions, and methods of use, for neutralizing Type I interferons in a mammal. The compositions contain a soluble Orthopoxvirus IFN-binding protein that is modified to remove the cell-binding region, and that specifically binds to Type I IFNs, and a pharmaceutically acceptable carrier or excipient. Another variation of the invention entails a novel IFN-binding protein that is modified to remove the cell-binding region and the signal sequence.