Targeted expansion of Qa-1-peptide-specific regulatory CD8 T cells to ameliorate arthritis
US10548957B2 · kind B2 · utility
6Cited by
3References
5Claims
0Family size
Assignee
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Key dates
| Filing date | Sep 26, 2013 |
| Grant date | Feb 4, 2020 |
| Priority date | — |
| Expiry date | Jan 20, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2501/2315
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Nanoparticles to treat autoimmune diseases and HIV infection are provided. The nanoparticles comprise a biocompatible polymer and a complex, wherein the complex is a major histocompatibility complex (MHC) class I antigen E (HLA-E) linked to a peptide, and wherein the HLA-E-peptide complex is linked to the surface of the nanoparticle. The present invention also relates to methods for treating autoimmune diseases and HIV infection.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.