Cover member, method and treatment module for treating a biological sample on a substrate

US10549271B2 · kind B2 · utility

Assignee

• LEICA BIOSYSTEMS MELBOURNE PTY LTD · AU

Inventors

• Mark Brian Dockrill · Melbourne, AU
• Anthony Favaloro · Melbourne, AU
• Kenneth Heng-Chong Ng · Cottles Bridge, AU
• Martin Limon · Melbourne, AU
• Peter Toogood · Melbourne, AU
• Stephen John Bagnato · Sydney, AU

Key dates

• Filing date: Nov 15, 2012
• Grant date: Feb 4, 2020
• Expiry date: Jul 3, 2033

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T436/25
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A cover member for a substrate supporting a biological sample comprises first and second opposing ends, first and second opposing surfaces, a void in the second surface which, when juxtaposed with a substrate, forms a chamber, and a fluid inlet toward the first end and in fluid communication with the void. The void is bounded by void walls having one or more contoured regions for enhancing fluid movement within the chamber. A treatment module for a biological sample comprises the cover member, a support surface for a substrate bearing the biological sample and clamp means operable to releasably retain the cover member in juxtaposition with the substrate for an incubation period. A method for incubating the biological sample with one or more reagents uses the cover member.